InterPAD - DETAILS

cyanidin 3-O-beta-D-glucoside, cyanidin 3-O-glucoside, cyanidin-3,5-diglucoside, cyanidin-3-glucoside, cyanidin-3-O-beta-glucopyranoside, cyanidin-3-O-beta-glucoside

No.	Title	Href
1	Cyanidin-3-O-glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells. J Food Sci. 2021 Jun;86(6):2700-2712. doi: 10.1111/1750-3841.15740.	`Click`
2	Combination of cyanidin-3-O-glucoside and cisplatin induces oxidative stress and apoptosis in HeLa cells by reducing activity of endogenous antioxidants, increasing bax/bcl-2 mRNA expression ratio, and downregulating Nrf2 expression. J Food Biochem. 2021 Jul;45(7):e13806. doi: 10.1111/jfbc.13806.	`Click`

No.

Title

Href

Cyanidin-3-O-glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells. J Food Sci. 2021 Jun;86(6):2700-2712. doi: 10.1111/1750-3841.15740.

Click

Combination of cyanidin-3-O-glucoside and cisplatin induces oxidative stress and apoptosis in HeLa cells by reducing activity of endogenous antioxidants, increasing bax/bcl-2 mRNA expression ratio, and downregulating Nrf2 expression. J Food Biochem. 2021 Jul;45(7):e13806. doi: 10.1111/jfbc.13806.

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Name	Kuromanin chloride
PubChem CID	197081
Molecular Weight	484.8g/mol
Synonyms	cyanidin 3-O-beta-D-glucoside, cyanidin 3-O-glucoside, cyanidin-3,5-diglucoside, cyanidin-3-glucoside, cyanidin-3-O-beta-glucopyranoside, cyanidin-3-O-beta-glucoside
Formula	C₂₁H₂₁ClO₁₁
SMILES	C1=CC(=C(C=C1C2=[O+]C3=CC(=CC(=C3C=C2OC4C(C(C(C(O4)CO)O)O)O)O)O)O)O.[Cl-]
InChI	1S/C21H20O11.ClH/c22-7-16-17(27)18(28)19(29)21(32-16)31-15-6-10-12(25)4-9(23)5-14(10)30-20(15)8-1-2-11(24)13(26)3-8;/h1-6,16-19,21-22,27-29H,7H2,(H3-,23,24,25,26);1H/t16-,17-,18+,19-,21-;/m1./s1
InChIKey	YTMNONATNXDQJF-UBNZBFALSA-N
CAS Number	7084-24-4
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	DiYu
Use Part	Root
Habitat	Shaanxi, GanSu, QingHai, NingXia, XinJiang, HeiLongJiang, JiLin, LiaoNing
Flavor	Bitter, Sour, Astringent
Meridian Tropism	Liver, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rosaceae 　　　　　-->Genus: Sanguisorba 　　　　　　-->Species: Sanguisorba officinalis

Chineses Pinyin	Sang
Use Part	Leaf; Root; Branche; Fruit
Habitat	China
Flavor	Sweet
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Moraceae 　　　　　-->Genus: Morus 　　　　　　-->Species: Morus alba

Pair Name	Kuromanin chloride, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C77.Z]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	GABPA	hsa2551
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	These results expanded our understanding of the role of C3G in a cervical cancer cell model, and provided a potential new treatment strategy for this cancer, as well as a theoretical basis for the development of new drugs in the future.

Pair Name	Kuromanin chloride, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C77.Z]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Activity	BAX	hsa581
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Activity	TP53	hsa7157
	Up-regulation	Activity	TIMP1	hsa7076
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	MTOR	hsa2475
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	Cyanidin-3-O-glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells